Líneas de Investigación
- Mecanismos celulares y moleculares de la plasticidad de sinapsis GABAérgicas
- Neuromodulación de la transmisión GABAérgica
- Bases sináptica de enfermedades psiquiátricas: Esquizofrenia.
Proyectos Vigentes
2024-2027 Proyecto FONDECYT Regular: Restoring parvalbumin interneuron function reverts long-lasting consequences of adolescent ketamine exposure on dentate gyrus function and recognition memory. Rol: Investigador Responsable
Publicaciones
Maternal immune activation alters temporal precision of spike generation of CA1 pyramidal neurons by unbalancing GABAergic inhibition intheOffspring. Brain Behav Immun. 2024 Sep 16:S0889-1591(24)00616-0. doi: 10.1016/j.bbi.2024.09.012. Online ahead of print.
Enhanced Astrocyte Activity and Excitatory Synaptic Function in the Hippocampus of Pentylenetetrazole Kindling Model of Epilepsy. Int J Mol Sci. 2023 Sep 25;24(19):14506. doi: 10.3390/ijms241914506.
Central and Peripheral Inflammation: A Common Factor Causing Addictive and Neurological Disorders and Aging-Related Pathologies. Int J Mol Sci. 2023 Jun 13;24(12):10083. doi: 10.3390/ijms241210083.
Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity. Biomolecules. 2023 May 25;13(6):887. doi: 10.3390/biom13060887.
The Long-Term Pannexin 1 Ablation Produces Structural and Functional Modifications in Hippocampal Neurons. Flores-Muñoz C, García-Rojas F, Pérez MA, Santander O, Mery E, Ordenes S, Illanes-González J, López-Espíndola D, González-Jamett AM, Fuenzalida M, Martínez AD, Ardiles AO. Cells 2022, 11(22), 3646; https://doi.org/10.3390/cells11223646
P2Y1 receptor inhibition rescues impaired synaptic plasticity and astroglial Ca2+-dependent activity in the epileptic hippocampus. Neurobiol Dis. 2020 Oct 10;146:105132. doi: 10.1016/j.nbd.2020.105132
Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus. Neuroscience. 2020 Aug 20:S0306-4522(20)30524-8. doi: 10.1016/j.neuroscience.2020.08.015
Cannabinoid Signaling Selectively Modulates GABAergic Inhibitory Input to OFF Bipolar Cells in Rat Retina. Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):3. doi: 10.1167/iovs.61.3.3.
Priming of GABAergic long-term potentiation by muscarinic receptors. Morales-Weil K, Moreno M, Ahumada J, Arriagada J, Fuentealba P, Bonansco C, Fuenzalida M. Neuroscience. 2020 Jan 6. pii: S0306-4522(19)30888-7. doi: 10.1016/j.neuroscience.2019.12.033.
The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability. Pérez V, Bermedo-Garcia F, Zelada D, Court FA, Pérez MÁ, Fuenzalida M, Ábrigo J, Cabello-Verrugio C, Moya-Alvarado G, Tapia JC, Valenzuela V, Hetz C, Bronfman FC, Henríquez JP. Acta Neuropathol Commun. 2019 Sep 12;7(1):147. doi: 10.1186/s40478-019-0802-7.
Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats. Pérez MÁ, Morales C, Santander O, García F, Gómez I, Peñaloza-Sancho V, Fuentealba P, Dagnino-Subiabre A, Moya PR, Fuenzalida M. Front Cell Neurosci. 2019 Aug 20;13:372. doi: 10.3389/fncel.2019.00372. eCollection 2019.
Coordinated prefrontal-hippocampal activity and navigation strategy-related prefrontal firing during spatial memory formation. Negrón-Oyarzo I, Espinosa N, Aguilar-Rivera M, Fuenzalida M, Aboitiz F, Fuentealba P. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7123-7128. doi: 10.1073/pnas.1720117115. Epub 2018 Jun 18.
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer’s disease mice. Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henríquez B, Guerra MV, Stehberg J, Neve RL, Inestrosa NC, Wyneken U, Fuenzalida M, Härtel S, Sena-Esteves M, Varela-Nallar L, Rots MG, Montecino M, van Zundert B. Brain. 2017 Dec 1;140(12):3252-3268. doi: 10.1093/brain/awx272.
n-3 Polyunsaturated fatty acid supplementation restored impaired memory and GABAergic synaptic efficacy in the hippocampus of stressed rats. Pérez MÁ, Peñaloza-Sancho V, Ahumada J, Fuenzalida M, Dagnino-Subiabre A. Nutr Neurosci. 2018 Oct;21(8):556-569. doi: 10.1080/1028415X.2017.1323609. Epub 2017 May 8.
Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks. Perea G, Gómez R, Mederos S, Covelo A, Ballesteros JJ, Schlosser L, Hernández-Vivanco A, Martín-Fernández M, Quintana R, Rayan A, Díez A, Fuenzalida M, Agarwal A, Bergles DE, Bettler B, Manahan-Vaughan D, Martín ED, Kirchhoff F, Araque A. Elife. 2016 Dec 24;5. pii: e20362. doi: 10.7554/eLife.20362.
Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain. Bonansco C, Fuenzalida M. Neural Plast. 2016;2016:8607038. doi: 10.1155/2016/8607038. Epub 2016 Feb 24. Review.
Role of Nicotinic and Muscarinic Receptors on Synaptic Plasticity and Neurological Diseases. Fuenzalida M, Pérez MÁ, Arias HR. Curr Pharm Des. 2016;22(14):2004-14. Review.
Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy. Fuenzalida M, Espinoza C, Pérez MÁ, Tapia-Rojas C, Cuitino L, Brandan E, Inestrosa NC. Neurobiol Dis. 2016 Feb;86:109-20. doi: 10.1016/j.nbd.2015.11.018. Epub 2015 Dec 2.
Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength in the epileptic brain. Álvarez-Ferradas C, Morales JC, Wellmann M, Nualart F, Roncagliolo M, Fuenzalida M, Bonansco C. Glia. 2015 Sep;63(9):1507-21. doi: 10.1002/glia.22817. Epub 2015 May 15.
WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by Aβ oligomers. Vargas JY, Ahumada J, Arrázola MS, Fuenzalida M, Inestrosa NC. Exp Neurol. 2015 Feb;264:14-25. doi: 10.1016/j.expneurol.2014.11.005. Epub 2014 Nov 20.